Peptide Information

General Information of This Peptide
Peptide ID
BTDP008379
Peptide Name
Kappa-conotoxin PVIIA
Symonym
CGX-1051; Fin-popping peptide
Species
Conus purpurascens (Purple cone)
Uniprot Name
O17A_CONPU
Alphafold ID
P56633
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1AV3
Sequence
MKLTCVVIVVVLFLTACQLITADDSRRTQKHRALRSTTKLSLSTRCRIPNQKCFQHLDDC
CSRKCNRFNKCV
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Sequence Length
72
Mass (Da)
8317
Signal Sequence
MKLTCVVIVVVLFLTACQLITA
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Sequence Removed Signal Peptide
DDSRRTQKHRALRSTTKLSLSTRCRIPNQKCFQHLDDCCSRKCNRFNKCV
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Disulfide Bond
46-61;53-65;60-71
PDB ID
1AV3 , 1KCP , 2N8E
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus purpurascens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
1 μM
Modifier
 [1- 12]
 Target Info    Kv1 Inhibition rate .
1 μM
Modifier
 [1- 12]
 Target Info    Shaker IR potassium channel IC50
57 - 80 nM
 .
Modifier
 [1- 12]
 Target Info    Shaker IC50
60 nM
 .
Modifier
 [1- 12]
References
Ref 1 kappa-Conotoxin PVIIA is a peptide inhibiting the shaker K+ channel. J Biol Chem. 1998 Jan 2;273(1):33-8. doi: 10.1074/jbc.273.1.33.
Ref 2 Strategy for rapid immobilization of prey by a fish-hunting marine snail. Nature. 1996 May 9;381(6578):148-51. doi: 10.1038/381148a0.
Ref 3 The block of Shaker K+ channels by kappa-conotoxin PVIIA is state dependent. J Gen Physiol. 1999 Jul;114(1):125-40. doi: 10.1085/jgp.114.1.125.
Ref 4 Single amino acid substitutions in kappa-conotoxin PVIIA disrupt interaction with the shaker K+ channel. J Biol Chem. 2000 Aug 11;275(32):24639-44. doi: 10.1074/jbc.C900990199.
Ref 5 Molecular simulation of the interaction of kappa-conotoxin-PVIIA with the Shaker potassium channel pore. Eur Biophys J. 2001 Dec;30(7):528-36. doi: 10.1007/s00249-001-0189-8.
Ref 6 Inhibition of single Shaker K channels by kappa-conotoxin-PVIIA. Biophys J. 2002 Jun;82(6):3003-11. doi: 10.1016/S0006-3495(02)75641-5.
Ref 7 Electrostatic recognition and induced fit in the kappa-PVIIA toxin binding to Shaker potassium channel. J Am Chem Soc. 2005 May 11;127(18):6836-49. doi: 10.1021/ja042641q.
Ref 8 Postischemic administration of CGX-1051, a peptide from cone snail venom, reduces infarct size in both rat and dog models of myocardial ischemia and reperfusion. J Cardiovasc Pharmacol. 2005 Aug;46(2):141-6. doi: 10.1097/01.fjc.0000167015.84715.27.
Ref 9 Why the Drosophila Shaker K+ channel is not a good model for ligand binding to voltage-gated Kv1 channels. Biochemistry. 2013 Mar 5;52(9):1631-40. doi: 10.1021/bi301257p. Epub 2013 Feb 20.
Ref 10 Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnol Bioeng. 2016 Oct;113(10):2202-12. doi: 10.1002/bit.25993. Epub 2016 Aug 9.
Ref 11 Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA. Structure. 1997 Dec 15;5(12):1585-97. doi: 10.1016/s0969-2126(97)00307-9.
Ref 12 Three-dimensional structure of kappa-conotoxin PVIIA, a novel potassium channel-blocking toxin from cone snails. Biochemistry. 1998 Apr 21;37(16):5407-16. doi: 10.1021/bi9730341.
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