Peptide Information

General Information of This Peptide
Peptide ID
BTDP007741
Peptide Name
Erabutoxin b
Symonym
Short neurotoxin 1b
Species
Laticauda semifasciata (Black-banded sea krait) (Pseudolaticauda semifasciata)
Uniprot Name
3S1EB_LATSE
Alphafold ID
Q90VW1
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1ERA
Sequence
MKTLLLTLVVVTIVCLDLGYTRICFNHQSSQPQTTKTCSPGESSCYHKQWSDFRGTIIER
GCGCPTVKPGIKLSCCESEVCNN
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Sequence Length
83
Mass (Da)
9160
Signal Sequence
MKTLLLTLVVVTIVCLDLGYT
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Sequence Removed Signal Peptide
RICFNHQSSQPQTTKTCSPGESSCYHKQWSDFRGTIIERGCGCPTVKPGIKLSCCESEVC
NN
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Disulfide Bond
24-45;38-62;64-75;76-81
PDB ID
1ERA , 1FRA , 1NXB , 3EBX , 6EBX
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Laticauda
Species: Laticauda semifasciata
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR Dissociation constant
0.07 nM
 . . [1- 13]
 Target Info    nAChR chimeric alpha-7 Dissociation constant
22 μM
 . . [1- 13]
References
Ref 1 Sequence analysis of a cDNA encoding a erabutoxin b from the sea-snake Laticauda semifasciata. Nucleic Acids Res. 1989 Dec 25;17(24):10490. doi: 10.1093/nar/17.24.10490.
Ref 2 Molecular evolution and diversification of snake toxin genes, revealed by analysis of intron sequences. Gene. 2003 Aug 14;313:111-8. doi: 10.1016/s0378-1119(03)00637-1.
Ref 3 The amino acid sequences of erabutoxins, neurotoxic proteins of sea-snake (Laticauda semifasciata) venom. Biochem J. 1971 May;122(4):453-61. doi: 10.1042/bj1220453.
Ref 4 Correction of partial amino acid sequence of erabutoxins. Biochem J. 1977 Oct 1;167(1):289-91. doi: 10.1042/bj1670289.
Ref 5 Protein sequencing by computer graphics. Biochim Biophys Acta. 1977 Apr 25;491(2):605-8. doi: 10.1016/0005-2795(77)90309-9.
Ref 6 Genetic engineering of snake toxins. The functional site of Erabutoxin a, as delineated by site-directed mutagenesis, includes variant residues. J Biol Chem. 1995 Apr 21;270(16):9362-9. doi: 10.1074/jbc.270.16.9362.
Ref 7 Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor. J Biol Chem. 1997 Sep 26;272(39):24279-86. doi: 10.1074/jbc.272.39.24279.
Ref 8 The crystal structure of a post-synaptic neurotoxin from sea snake at A resolution. FEBS Lett. 1976 Sep 15;68(1):1-4. doi: 10.1016/0014-5793(76)80390-0.
Ref 9 Structure and function of snake venom curarimimetic neurotoxins. Mol Pharmacol. 1978 Jul;14(4):710-6.
Ref 10 Molecular conformation of erabutoxin b; atomic coordinates at 2.5 A resolution. Biochem Biophys Res Commun. 1979 Jun 13;88(3):950-9. doi: 10.1016/0006-291x(79)91500-6.
Ref 11 Erabutoxin b. Structure/function relationships following initial protein refinement at 0.140-nm resolution. Eur J Biochem. 1986 Dec 15;161(3):579-87. doi: 10.1111/j.1432-1033.1986.tb10481.x.
Ref 12 Structure determination of a dimeric form of erabutoxin-b, crystallized from a thiocyanate solution. Acta Crystallogr B. 1992 Aug 1;48 ( Pt 4):520-31. doi: 10.1107/s010876819200096x.
Ref 13 Tertiary structure of erabutoxin b in aqueous solution as elucidated by two-dimensional nuclear magnetic resonance. J Mol Biol. 1994 Jul 8;240(2):155-66. doi: 10.1006/jmbi.1994.1429.
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