Peptide Information

General Information of This Peptide
Peptide ID
BTDP007564
Peptide Name
Alpha-bungarotoxin, isoform A31
Symonym
Alpha-BgTx (A31); Alpha-bungarotoxin (A31)
Species
Bungarus candidus (Malayan krait)
Uniprot Name
3L2A_BUNCA
Alphafold ID
Q7T3J2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q7T3J2
Sequence
MKTLLLTLVVVTIVCLDLGYTIVCHTTATSPISAVTCPPGENLCYRKMWCDAFCSSRGKV
VELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG
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Sequence Length
95
Mass (Da)
10285
Signal Sequence
MKTLLLTLVVVTIVCLDLGYT
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Sequence Removed Signal Peptide
IVCHTTATSPISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKPYEEVTCC
STDKCNPHPKQRPG
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Disulfide Bond
24-44;37-65;50-54;69-80;81-86
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Bungarus
Species: Bungarus candidus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR Dissociation constant
0.4 nM
 . . [1], [2]
 Target Info    nAChR chimeric alpha-7 Dissociation constant
0.95 nM
 . . [1], [2]
 Target Info    recombinant GABA(A) receptor beta-3/GABRB3 subunit Dissociation constant
50 nM
 . . [1], [2]
 Target Info    GABA(A) Inhibition rate
62.3 %
20 μM
 . [1], [2]
References
Ref 1 Identification of alpha-bungarotoxin (A31) as the major postsynaptic neurotoxin, and complete nucleotide identity of a genomic DNA of Bungarus candidus from Java with exons of the Bungarus multicinctus alpha-bungarotoxin (A31) gene. Toxicon. 2003 Sep 15;42(4):381-90. doi: 10.1016/s0041-0101(03)00168-5.
Ref 2 Novel long-chain neurotoxins from Bungarus candidus distinguish the two binding sites in muscle-type nicotinic acetylcholine receptors. Biochem J. 2019 Apr 26;476(8):1285-1302. doi: 10.1042/BCJ20180909.
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