Peptide Information

General Information of This Peptide
Peptide ID
BTDP006818
Peptide Name
Sodium channel neurotoxin MeuNaTxalpha-1
Species
Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Uniprot Name
SCXN1_MESEU
Alphafold ID
P86408
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6THI
Sequence
MNSLVMISLALLVMTGVESVRDGYIADDKNCAYFCGRNAYCDEECKKKGAESGYCQWAGQ
YGNACWCYKLPDKVPIKVSGKCNGR
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Sequence Length
85
Mass (Da)
9390
Signal Sequence
MNSLVMISLALLVMTGVES
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Sequence Removed Signal Peptide
VRDGYIADDKNCAYFCGRNAYCDEECKKKGAESGYCQWAGQYGNACWCYKLPDKVPIKVS
GKCNGR
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Disulfide Bond
31-82;35-55;41-65;45-67
PDB ID
6THI
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus eupeus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Para/DmNav1 Effective concentration 50
1.17 μM
 . . [1], [2], [3]
 Target Info    Nav1.6 Effective concentration 50
3.1 μM
 . . [1], [2], [3]
References
Ref 1 Evolutionary diversification of Mesobuthus -scorpion toxins affecting sodium channels. Mol Cell Proteomics. 2012 Jan;11(1):M111.012054. doi: 10.1074/mcp.M111.012054. Epub 2011 Oct 3.
Ref 2 Scorpion toxin MeuNaTx-1 sensitizes primary nociceptors by selective modulation of voltage-gated sodium channels. FEBS J. 2021 Apr;288(7):2418-2435. doi: 10.1111/febs.15593. Epub 2020 Nov 5.
Ref 3 Structure of MeuNaTx-1 toxin from scorpion venom highlights the importance of the nest motif. Proteins. 2021 Mar 13. doi: 10.1002/prot.26074. Online ahead of print.
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