Peptide Information

General Information of This Peptide
Peptide ID
BTDP006671
Peptide Name
Mu-conotoxin SrVA
Symonym
Conotoxin sr5a; Sr5.1; Sr5.2; Sr5.3
Species
Conus spurius (Alphabet cone)
Uniprot Name
CT5A_CONSP
Alphafold ID
P84845
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P84845
Sequence
MRCLPVFVILLLLIASAPSVDAQLKTKDDVPLASFHDNAKGTQHKRIINWCCLIFYQCC
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Sequence Length
59
Mass (Da)
6663
Signal Sequence
MRCLPVFVILLLLIASAPSVDA
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Sequence Removed Signal Peptide
QLKTKDDVPLASFHDNAKGTQHKRIINWCCLIFYQCC
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Disulfide Bond
51-58;52-59
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus spurius
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 Inhibition rate
7 %
200 μM
 . [1], [2], [3]
 Target Info    Nav1.6 Inhibition rate
14 %
200 μM
 . [1], [2], [3]
 Target Info    Nav1.5 Inhibition rate
33 %
200 nM
 . [1], [2], [3]
 Target Info    Nav1.5 Inhibition rate
50 %
400 nM
 . [1], [2], [3]
 Target Info    Nav1.5 Inhibition rate
55 %
600 nM
 . [1], [2], [3]
References
Ref 1 Identification, by RT-PCR, of four novel T-1-superfamily conotoxins from the vermivorous snail Conus spurius from the Gulf of Mexico. Peptides. 2009 Aug;30(8):1396-404. doi: 10.1016/j.peptides.2009.05.003. Epub 2009 May 15.
Ref 2 A biologically active hydrophobic T-1-conotoxin from the venom of Conus spurius. Peptides. 2006 Mar;27(3):500-5. doi: 10.1016/j.peptides.2005.07.020. Epub 2005 Nov 16.
Ref 3 The T-1 conotoxin -SrVA from the worm hunting marine snail Conus spurius preferentially blocks the human Na(V)1.5 channel. Peptides. 2022 Oct;156:170859. doi: 10.1016/j.peptides.2022.170859. Epub 2022 Aug 5.
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