Peptide Information

General Information of This Peptide
Peptide ID
BTDP006502
Peptide Name
Kininogen-2
Symonym
BOK-2
Species
Bombina orientalis (Oriental fire-bellied toad)
Uniprot Name
BRK2_BOMOR
Alphafold ID
P83059
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P83059
Sequence
MRLWFCLSFFVVLCLEHFPGTLADERNNRDYPIRTHLHGPHIPRNNRDYPIRTHLHGHHI
PRNVPESEEKTEQFLRDLSEISRLQRRPPGFTPFRGKFHSQSLRDLSEISRLQRRPPGFT
PFRGKFHSQSLRDMYEIKGFKSAHGRPRVCPPGEQCPIWVG
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Sequence Length
161
Mass (Da)
19042
Signal Sequence
MRLWFCLSFFVVLCLEHFPGTLA
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Sequence Removed Signal Peptide
DERNNRDYPIRTHLHGPHIPRNNRDYPIRTHLHGHHIPRNVPESEEKTEQFLRDLSEISR
LQRRPPGFTPFRGKFHSQSLRDLSEISRLQRRPPGFTPFRGKFHSQSLRDMYEIKGFKSA
HGRPRVCPPGEQCPIWVG
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Disulfide Bond
150-156
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Kingdom: Metazoa
Phylum: Chordata
Class: Amphibia
Order: Anura
Family: Bombinatoridae
Genus: Bombina
Species: Bombina orientalis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    angiotensin-I converting enzyme (ACE) Inhibition constant
1.6 μM
 .
[Thr6]-bradykinin]
 [1], [2]
References
Ref 1 Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis). Peptides. 2002 Sep;23(9):1547-55. doi: 10.1016/s0196-9781(02)00095-5.
Ref 2 Peptide DV-28 amide: An inhibitor of bradykinin-induced arterial smooth muscle relaxation encoded by Bombina orientalis skin kininogen-2. Peptides. 2010 May;31(5):979-82. doi: 10.1016/j.peptides.2010.01.016. Epub 2010 Feb 6.
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