Peptide Information

General Information of This Peptide
Peptide ID
BTDP006369
Peptide Name
Adrenergic toxin rho-elapitoxin-Dp1a
Symonym
Muscarinic toxin beta
Species
Dendroaspis polylepis polylepis (Black mamba)
Uniprot Name
3SIMB_DENPO
Alphafold ID
P80495
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P80495
Sequence
LTCVTSKSIFGITTEDCPDGQNLCFKRRHYVVPKIYDITRGCVATCPIPENYDSIHCCKT
DKCNE
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Sequence Length
65
Mass (Da)
7345
Sequence Removed Signal Peptide
LTCVTSKSIFGITTEDCPDGQNLCFKRRHYVVPKIYDITRGCVATCPIPENYDSIHCCKT
DKCNE
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Disulfide Bond
3-24;17-42;46-57;58-63
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis polylepis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    CHRM4 Inhibition constant
120 nM
 . . [1], [2], [3], [4]
 Target Info    CHRM3 Inhibition constant
140 nM
 . . [1], [2], [3], [4]
 Target Info    CHRM5 Inhibition constant
350 nM
 . . [1], [2], [3], [4]
 Target Info    CHRM1 and CHRM2 Inhibition constant
>1 μM
 . . [1], [2], [3], [4]
References
Ref 1 Muscarinic toxins from the black mamba Dendroaspis polylepis. Eur J Biochem. 1995 Dec 1;234(2):579-85. doi: 10.1111/j.1432-1033.1995.579_b.x.
Ref 2 Protein toxins that bind to muscarinic acetylcholine receptors. Ann N Y Acad Sci. 1994 Mar 9;710:153-61. doi: 10.1111/j.1749-6632.1994.tb26623.x.
Ref 3 Kinetic evidence for different mechanisms of interaction of black mamba toxins MT alpha and MT beta with muscarinic receptors. Toxicon. 2001 Feb-Mar;39(2-3):377-82. doi: 10.1016/s0041-0101(00)00141-0.
Ref 4 New -adrenergic property for synthetic MT and CM-3 three-finger fold toxins from black mamba. Toxicon. 2013 Dec 1;75:160-7. doi: 10.1016/j.toxicon.2013.04.017. Epub 2013 May 3.
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