Peptide Information

General Information of This Peptide
Peptide ID
BTDP006230
Peptide Name
Erabutoxin a
Symonym
Short neurotoxin 1a
Species
Laticauda semifasciata (Black-banded sea krait) (Pseudolaticauda semifasciata)
Uniprot Name
3S1EA_LATSE
Alphafold ID
P60775
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1QKD
Sequence
MKTLLLTLVVVTIVCLDLGYTRICFNHQSSQPQTTKTCSPGESSCYNKQWSDFRGTIIER
GCGCPTVKPGIKLSCCESEVCNN
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Sequence Length
83
Mass (Da)
9137
Signal Sequence
MKTLLLTLVVVTIVCLDLGYT
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Sequence Removed Signal Peptide
RICFNHQSSQPQTTKTCSPGESSCYNKQWSDFRGTIIERGCGCPTVKPGIKLSCCESEVC
NN
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Disulfide Bond
24-45;38-62;64-75;76-81
PDB ID
1QKD , 1QKE , 2ERA , 3ERA , 5EBX
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Laticauda
Species: Laticauda semifasciata
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR chimeric alpha-7 Dissociation constant
0.07 nM
 . . [1- 13]
 Target Info    nAChR Dissociation constant
21 μM
 . . [1- 13]
References
Ref 1 Cloning and sequence analysis of the cDNA encoding a snake neurotoxin precursor. Biochimie. 1985 Feb;67(2):185-9. doi: 10.1016/s0300-9084(85)80046-8.
Ref 2 Molecular evolution and diversification of snake toxin genes, revealed by analysis of intron sequences. Gene. 2003 Aug 14;313:111-8. doi: 10.1016/s0378-1119(03)00637-1.
Ref 3 The amino acid sequences of erabutoxins, neurotoxic proteins of sea-snake (Laticauda semifasciata) venom. Biochem J. 1971 May;122(4):453-61. doi: 10.1042/bj1220453.
Ref 4 Correction of partial amino acid sequence of erabutoxins. Biochem J. 1977 Oct 1;167(1):289-91. doi: 10.1042/bj1670289.
Ref 5 The disulphide bonds of erabutoxin a, a neurotoxic protein of a sea-snake (Laticauda semifasciata) venom. Biochem J. 1971 May;122(4):463-7. doi: 10.1042/bj1220463.
Ref 6 Genetic engineering of snake toxins. Role of invariant residues in the structural and functional properties of a curaremimetic toxin, as probed by site-directed mutagenesis. J Biol Chem. 1993 Jan 15;268(2):909-16.
Ref 7 Genetic engineering of snake toxins. The functional site of Erabutoxin a, as delineated by site-directed mutagenesis, includes variant residues. J Biol Chem. 1995 Apr 21;270(16):9362-9. doi: 10.1074/jbc.270.16.9362.
Ref 8 Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor. J Biol Chem. 1997 Sep 26;272(39):24279-86. doi: 10.1074/jbc.272.39.24279.
Ref 9 Effects of alpha-erabutoxin, alpha-bungarotoxin, alpha-cobratoxin and fasciculin on the nicotine-evoked release of dopamine in the rat striatum in vivo. Neurochem Int. 1998 Oct;33(4):307-12. doi: 10.1016/s0197-0186(98)00033-3.
Ref 10 Three-dimensional structure of neurotoxin a from venom of the Philippines sea snake. Proc Natl Acad Sci U S A. 1977 Mar;74(3):971-4. doi: 10.1073/pnas.74.3.971.
Ref 11 The crystal structure of erabutoxin a at 2.0-A resolution. J Biol Chem. 1989 Jun 5;264(16):9239-42. doi: 10.2210/pdb5ebx/pdb.
Ref 12 Structure of dimeric and monomeric erabutoxin a refined at 1.5 A resolution. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):964-74. doi: 10.1107/s0907444998005125.
Ref 13 High resolution x-ray analysis of two mutants of a curaremimetic snake toxin. Eur J Biochem. 2000 Mar;267(5):1323-9. doi: 10.1046/j.1432-1327.2000.01099.x.
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