Peptide Information

General Information of This Peptide
Peptide ID
BTDP006119
Peptide Name
Sigma-conotoxin GVIIIA
Species
Conus geographus (Geography cone) (Nubecula geographus)
Uniprot Name
CS8A_CONGE
Alphafold ID
P58924
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P58924
Sequence
MMSKMGAMFVLLLLFTLASSLQEGDVQARKTRLKSDFYRALARDDRGCTRTCGGPKCTGT
CTCTNSSKCGCRYNVHPSGWGCGCACSG
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Sequence Length
88
Mass (Da)
9430
Signal Sequence
MMSKMGAMFVLLLLFTLASS
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Sequence Removed Signal Peptide
LQEGDVQARKTRLKSDFYRALARDDRGCTRTCGGPKCTGTCTCTNSSKCGCRYNVHPSGW
GCGCACSG
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus geographus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    5-hydroxytryptamine 3 receptor (HTR3A) IC50
53 - 86.8 nM
 . . [1], [2], [3]
References
Ref 1 Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol Phylogenet Evol. 2010 Jul;56(1):1-12. doi: 10.1016/j.ympev.2010.03.029. Epub 2010 Apr 2.
Ref 2 Inactivation of a serotonin-gated ion channel by a polypeptide toxin from marine snails. Science. 1998 Jul 24;281(5376):575-8. doi: 10.1126/science.281.5376.575.
Ref 3 S-conotoxin GVIIIB potently and selectively blocks 910 nicotinic acetylcholine receptors. Biochem Pharmacol. 2015 Aug 15;96(4):349-56. doi: 10.1016/j.bcp.2015.06.007. Epub 2015 Jun 11.
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