Peptide Information

General Information of This Peptide
Peptide ID
BTDP006110
Peptide Name
Delta-conotoxin PVIA
Symonym
Lockjaw peptide
Species
Conus purpurascens (Purple cone)
Uniprot Name
O16A_CONPU
Alphafold ID
P58913
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P58913
Sequence
MKLTCVMIVAVLFLTAWTFVTADDSKNGLENHFWKARDEMKNREASKLDKKEACYAPGTF
CGIKPGLCCSEFCLPGVCFGG
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Sequence Length
81
Mass (Da)
8945
Signal Sequence
MKLTCVMIVAVLFLTAWTFVTA
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Sequence Removed Signal Peptide
DDSKNGLENHFWKARDEMKNREASKLDKKEACYAPGTFCGIKPGLCCSEFCLPGVCFGG
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Disulfide Bond
54-69;61-73;68-78
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus purpurascens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 Effective concentration 50
1.9 μM
 . . [1], [2], [3], [4]
 Target Info    Nav1.2 Effective concentration 50
2.9 μM
 . . [1], [2], [3], [4]
 Target Info    Nav1.4 Effective concentration 50
5.2 μM
 . . [1], [2], [3], [4]
 Target Info    Nav1.7 Effective concentration 50
6.4 μM
 . . [1], [2], [3], [4]
References
Ref 1 Purification, characterization, synthesis, and cloning of the lockjaw peptide from Conus purpurascens venom. Biochemistry. 1995 Apr 18;34(15):4913-8. doi: 10.1021/bi00015a002.
Ref 2 Strategy for rapid immobilization of prey by a fish-hunting marine snail. Nature. 1996 May 9;381(6578):148-51. doi: 10.1038/381148a0.
Ref 3 Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA. J Neurosci. 2000 Jan 1;20(1):76-80. doi: 10.1523/JNEUROSCI.20-01-00076.2000.
Ref 4 Delta-conotoxin structure/function through a cladistic analysis. Biochemistry. 2001 Nov 6;40(44):13201-8. doi: 10.1021/bi010683a.
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