Peptide Information

General Information of This Peptide
Peptide ID
BTDP005215
Peptide Name
Alpha-conotoxin CIB
Symonym
C1.2
Species
Conus catus (Cat cone)
Uniprot Name
CA1B_CONCT
Alphafold ID
P0DPT2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DPT2
Sequence
SDGRNEAANDEASDVIELALKGCCSNPVCHLEHPNACGRRR
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Sequence Length
41
Mass (Da)
4409
Sequence Removed Signal Peptide
SDGRNEAANDEASDVIELALKGCCSNPVCHLEHPNACGRRR
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Disulfide Bond
23-29;24-37
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus catus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-1-beta-1-gamma-delta Inhibition rate .
10 μM
 . [1], [2]
 Target Info    nAChR alpha-4-beta-2 Inhibition rate .
10 μM
 . [1], [2]
 Target Info    nAChR alpha-3-beta-2 IC50
128.9 nM
 . . [1], [2]
 Target Info    nAChR alpha-7 IC50
1.511 μM
 . . [1], [2]
References
Ref 1 Evolution of Conus peptide genes: duplication and positive selection in the A-superfamily. J Mol Evol. 2010 Feb;70(2):190-202. doi: 10.1007/s00239-010-9321-7. Epub 2010 Feb 9.
Ref 2 Synthesis, Structure and Biological Activity of CIA and CIB, Two -Conotoxins from the Predation-Evoked Venom of Conus catus. Toxins (Basel). 2018 Jun 1;10(6):222. doi: 10.3390/toxins10060222.
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