Peptide Information

General Information of This Peptide
Peptide ID
BTDP005081
Peptide Name
Kappa-actitoxin-Avd4a
Symonym
Antihypertensive protein BDS-1; Blood depressing substance 1
Species
Anemonia viridis (Snakelocks anemone)
Uniprot Name
BDS1_ANEVI
Alphafold ID
P0DMX6
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DMX6
Sequence
MNKALFLCLVVLCAAVVFAAEDLQKAKHAPFKRAAPCFCSGKPGRGDLWILRGTCPGGYG
YTSNCYKWPNICCYPH
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Sequence Length
76
Mass (Da)
8343
Signal Sequence
MNKALFLCLVVLCAAVVFA
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Sequence Removed Signal Peptide
AEDLQKAKHAPFKRAAPCFCSGKPGRGDLWILRGTCPGGYGYTSNCYKWPNICCYPH
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Disulfide Bond
37-72;39-65;55-73
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Actiniidae
Genus: Anemonia
Species: Anemonia viridis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 Effective concentration 50
3 nM
 . . [1- 5]
 Target Info    Nav1.7 Effective concentration 50
300 nM
 . . [1- 5]
References
Ref 1 Comprehensive EST analysis of the symbiotic sea anemone, Anemonia viridis. BMC Genomics. 2009 Jul 23;10:333. doi: 10.1186/1471-2164-10-333.
Ref 2 A Low Molecular Weight Protein from the Sea Anemone Anemonia viridis with an Anti-Angiogenic Activity. Mar Drugs. 2018 Apr 19;16(4):134. doi: 10.3390/md16040134.
Ref 3 The mining of toxin-like polypeptides from EST database by single residue distribution analysis. BMC Genomics. 2011 Jan 31;12:88. doi: 10.1186/1471-2164-12-88.
Ref 4 Development of a rational nomenclature for naming peptide and protein toxins from sea anemones. Toxicon. 2012 Sep 15;60(4):539-50. doi: 10.1016/j.toxicon.2012.05.020. Epub 2012 Jun 5.
Ref 5 Evidence of accelerated evolution and ectodermal-specific expression of presumptive BDS toxin cDNAs from Anemonia viridis. Mar Drugs. 2013 Oct 30;11(11):4213-31. doi: 10.3390/md11114213.
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