Peptide Information

General Information of This Peptide
Peptide ID
BTDP004944
Peptide Name
Conopressin-T
Symonym
Con-T
Species
Conus tulipa (Fish-hunting cone snail) (Tulip cone)
Uniprot Name
CONOT_CONTU
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
CYIQNCLRV
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Sequence Length
9
Mass (Da)
1111
Sequence Removed Signal Peptide
CYIQNCLRV
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Disulfide Bond
16
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus tulipa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    oxytocin receptor (OXTR) Inhibition constant
108 nM
 . . [1]
 Target Info    V1aR Inhibition constant
319 nM
 . . [1]
 Target Info    oxytocin receptor (OXTR) Kact
37 nM
 . . [1]
 Target Info    V1aR Kinact
329 nM
 . . [1]
 Target Info    V1aR Activation rate
9 %
10 μM
 . [1]
 Target Info    vasopressin V1b and V2 receptor Inhibition rate .
10 μM
 . [1]
References
Ref 1 Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. J Biol Chem. 2008 Mar 14;283(11):7100-8. doi: 10.1074/jbc.M706477200. Epub 2008 Jan 2.
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