Peptide Information

General Information of This Peptide
Peptide ID
BTDP004854
Peptide Name
Mambalgin-2
Symonym
Pi-Dp2
Species
Dendroaspis polylepis polylepis (Black mamba)
Uniprot Name
3SX2_DENPO
Alphafold ID
P0DKS3
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MFA
Sequence
LKCFQHGKVVTCHRDMKFCYHNTGMPFRNLKLILQGCSSSCSETENNKCCSTDRCNK
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Sequence Length
57
Mass (Da)
6547
Sequence Removed Signal Peptide
LKCFQHGKVVTCHRDMKFCYHNTGMPFRNLKLILQGCSSSCSETENNKCCSTDRCNK
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Disulfide Bond
3-19;12-37;41-49;50-55
PDB ID
2MFA
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis polylepis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    acid-sensing ion channel (ASIC) IC50
21 - 55 nM
 . . [1- 5]
 Target Info    ASIC1a-ASIC2b IC50
61 nM
 . . [1- 5]
 Target Info    acid-sensing ion channel (ASIC) IC50
72 nM
 . . [1- 5]
 Target Info    acid-sensing ion channel (ASIC) IC50
103 - 192 nM
 . . [1- 5]
 Target Info    ASIC1a-ASIC2b IC50
246 - 252 nM
 . . [1- 5]
References
Ref 1 Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature. 2012 Oct 25;490(7421):552-5. doi: 10.1038/nature11494. Epub 2012 Oct 3.
Ref 2 Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels. Toxicon. 2013 Dec 1;75:187-204. doi: 10.1016/j.toxicon.2013.04.008. Epub 2013 Apr 26.
Ref 3 Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a. J Biol Chem. 2014 May 9;289(19):13363-73. doi: 10.1074/jbc.M114.561076. Epub 2014 Apr 2.
Ref 4 Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation. J Pept Sci. 2016 May;22(5):320-6. doi: 10.1002/psc.2868. Epub 2016 Mar 15.
Ref 5 Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1017-20. doi: 10.1002/anie.201308898. Epub 2013 Dec 9.
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