Peptide Information

General Information of This Peptide
Peptide ID
BTDP004077
Peptide Name
Alpha-conotoxin AnIB
Species
Conus anemone (Anemone cone)
Uniprot Name
CA1AB_CONAN
Alphafold ID
P0C1V7
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 7N20
Sequence
GGCCSHPACAANNQDYC
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Sequence Length
17
Mass (Da)
1714
Sequence Removed Signal Peptide
GGCCSHPACAANNQDYC
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Disulfide Bond
3-9;4-17
PDB ID
7N20 , 7N21 , 7N22 , 7N23
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus anemone
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3-beta-2 IC50
0.2 nM
 . . [1], [2]
 Target Info    nAChR alpha-3-beta-2 IC50
0.3 nM
 . . [1], [2]
 Target Info    nAChR alpha-7 IC50
76 nM
 . . [1], [2]
References
Ref 1 Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone. J Med Chem. 2004 Feb 26;47(5):1234-41. doi: 10.1021/jm031010o.
Ref 2 Posttranslational modifications of -conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Med Chem. 2021 Jul 26;12(9):1574-1584. doi: 10.1039/d1md00182e. eCollection 2021 Sep 23.
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