Peptide Information

General Information of This Peptide
Peptide ID
BTDP004069
Peptide Name
Alpha-conotoxin OmIA
Species
Conus omaria (Omaria cone)
Uniprot Name
CA1A_CONOM
Alphafold ID
P0C1R7
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2GCZ
Sequence
GCCSHPACNVNNPHICG
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Sequence Length
17
Mass (Da)
1726
Sequence Removed Signal Peptide
GCCSHPACNVNNPHICG
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Disulfide Bond
2-8;3-16
PDB ID
2GCZ , 7N43
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus omaria
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3-beta-2 IC50
11 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-7 IC50
27.1 - 59 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-3-beta-4 IC50
160 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-6/alpha-3-beta-2-beta-3 IC50
201 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-7 IC50
290 nM
 . . [1], [2], [3], [4]
References
Ref 1 Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors. J Biol Chem. 2006 Aug 25;281(34):24678-86. doi: 10.1074/jbc.M602969200. Epub 2006 Jun 27.
Ref 2 Species specificity of rat and human 7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists. Neuropharmacology. 2018 Sep 1;139:226-237. doi: 10.1016/j.neuropharm.2018.07.019. Epub 2018 Jul 17.
Ref 3 Unique Pharmacological Properties of -Conotoxin OmIA at 7 nAChRs. Front Pharmacol. 2021 Dec 8;12:803397. doi: 10.3389/fphar.2021.803397. eCollection 2021.
Ref 4 Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes. Biochem Biophys Res Commun. 2006 Jun 23;345(1):248-54. doi: 10.1016/j.bbrc.2006.04.099. Epub 2006 Apr 27.
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