Peptide Information

General Information of This Peptide
Peptide ID
BTDP003944
Peptide Name
Alpha-mammal toxin AaH2
Symonym
AaH II; Neurotoxin II
Species
Androctonus australis (Sahara scorpion)
Uniprot Name
SCX2_ANDAU
Alphafold ID
P01484
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1AHO
Sequence
MNYLVMISLALLFVTGVESVKDGYIVDDVNCTYFCGRNAYCNEECTKLKGESGYCQWASP
YGNACYCYKLPDHVRTKGPGRCHGR
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Sequence Length
85
Mass (Da)
9548
Signal Sequence
MNYLVMISLALLFVTGVES
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Sequence Removed Signal Peptide
VKDGYIVDDVNCTYFCGRNAYCNEECTKLKGESGYCQWASPYGNACYCYKLPDHVRTKGP
GRCHGR
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Disulfide Bond
31-82;35-55;41-65;45-67
PDB ID
1AHO , 1PTX , 1SEG , 4AEI , 6NT4
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Androctonus
Species: Androctonus australis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Effective concentration 50
2.2 nM
 .
Skeletal muscle
 [1- 10]
 Target Info    Nav1.2 Effective concentration 50
2.6 nM
 . . [1- 10]
 Target Info    Nav1.7 Effective concentration 50
6.8 nM
 .
Neuronal
 [1- 10]
References
Ref 1 Precursors of Androctonus australis scorpion neurotoxins. Structures of precursors, processing outcomes, and expression of a functional recombinant toxin II. J Biol Chem. 1989 Nov 15;264(32):19259-65.
Ref 2 The amino-acid sequence of neurotoxin II of Androctonus australis Hector. Eur J Biochem. 1972 Jul 24;28(3):381-8. doi: 10.1111/j.1432-1033.1972.tb01924.x.
Ref 3 Disulfide bonds of toxin II of the scorpion Androctonus australis Hector. Eur J Biochem. 1974 Sep 16;47(3):483-9. doi: 10.1111/j.1432-1033.1974.tb03716.x.
Ref 4 Characterization of Amm VIII from Androctonus mauretanicus mauretanicus: a new scorpion toxin that discriminates between neuronal and skeletal sodium channels. Biochem J. 2003 Nov 1;375(Pt 3):551-60. doi: 10.1042/BJ20030688.
Ref 5 Expression of the standard scorpion alpha-toxin AaH II and AaH II mutants leading to the identification of some key bioactive elements. Biochim Biophys Acta. 2005 May 25;1723(1-3):91-9. doi: 10.1016/j.bbagen.2005.01.008. Epub 2005 Jan 29.
Ref 6 The scorpion toxin Amm VIII induces pain hypersensitivity through gain-of-function of TTX-sensitive Na? channels. Pain. 2013 Aug;154(8):1204-15. doi: 10.1016/j.pain.2013.03.037. Epub 2013 Apr 6.
Ref 7 Orthorhombic crystals and three-dimensional structure of the potent toxin II from the scorpion Androctonus australis Hector. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7443-7. doi: 10.1073/pnas.85.20.7443.
Ref 8 Crystal structure of toxin II from the scorpion Androctonus australis Hector refined at 1.3 A resolution. J Mol Biol. 1994 Apr 22;238(1):88-103. doi: 10.1006/jmbi.1994.1270.
Ref 9 Ab initio structure determination and refinement of a scorpion protein toxin. Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):551-7. doi: 10.1107/S0907444997005386.
Ref 10 Molecular basis of the high insecticidal potency of scorpion alpha-toxins. J Biol Chem. 2004 Jul 23;279(30):31679-86. doi: 10.1074/jbc.M402048200. Epub 2004 May 8.
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