Peptide Information

General Information of This Peptide
Peptide ID
BTDP003862
Peptide Name
Alpha-elapitoxin-Nno2a
Symonym
Long neurotoxin 1; Neurotoxin I; NnoI
Species
Naja oxiana (Central Asian cobra) (Oxus cobra)
Uniprot Name
3L21_NAJOX
Alphafold ID
P01382
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1NTN
Sequence
ITCYKTPIPITSETCAPGQNLCYTKTWCDAWCGSRGKVIELGCAATCPTVESYQDIKCCS
TDDCNPHPKQKRP
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Sequence Length
73
Mass (Da)
8031
Sequence Removed Signal Peptide
ITCYKTPIPITSETCAPGQNLCYTKTWCDAWCGSRGKVIELGCAATCPTVESYQDIKCCS
TDDCNPHPKQKRP
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Disulfide Bond
3-22;15-43;28-32;47-58;59-64
PDB ID
1NTN , 1W6B
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Naja
Species: Naja oxiana
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR chimeric alpha-7 Dissociation constant
12 nM
 . . [1- 6]
References
Ref 1 Amino acid sequence of neurotoxin I from Naja naja oxiana venom. FEBS Lett. 1974 Sep 1;45(1):118-21. doi: 10.1016/0014-5793(74)80825-2.
Ref 2 Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor. J Biol Chem. 1997 Sep 26;272(39):24279-86. doi: 10.1074/jbc.272.39.24279.
Ref 3 Neurotoxins from snake venoms and -conotoxin ImI inhibit functionally active ionotropic -aminobutyric acid (GABA) receptors. J Biol Chem. 2015 Sep 11;290(37):22747-58. doi: 10.1074/jbc.M115.648824. Epub 2015 Jul 28.
Ref 4 Crystallization and preliminary x-ray diffraction study of neurotoxin-I from Naja naja oxiana venom. FEBS Lett. 1990 Aug 20;269(1):255-7. doi: 10.1016/0014-5793(90)81167-m.
Ref 5 Three-dimensional structure of neurotoxin-1 from Naja naja oxiana venom at 1.9 A resolution. FEBS Lett. 1993 Apr 5;320(2):111-7. doi: 10.1016/0014-5793(93)80073-4.
Ref 6 Solution structure of long neurotoxin NTX-1 from the venom of Naja naja oxiana by 2D-NMR spectroscopy. Eur J Biochem. 2004 Dec;271(23-24):4950-7. doi: 10.1111/j.1432-1033.2004.04465.x.
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