Peptide Information

General Information of This Peptide
Peptide ID
BTDP003743
Peptide Name
Alpha-conotoxin LvIA
Symonym
Alpha-CTx LvIA
Species
Conus lividus (Livid cone)
Uniprot Name
CA1A_CONLI
Alphafold ID
L8BU87
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MDQ
Sequence
FRGRDAAAKASGLVGLTDRRGCCSHPACNVDHPEICG
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Sequence Length
37
Mass (Da)
3841
Sequence Removed Signal Peptide
FRGRDAAAKASGLVGLTDRRGCCSHPACNVDHPEICG
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Disulfide Bond
22-28;23-36
PDB ID
2MDQ , 5XGL , 6M4X , 6M4Z
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus lividus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3-beta-2 IC50
8.67 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-3-beta-2 IC50
17.5 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-6/alpha-3-beta-2-beta-3 IC50
108 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-6/alpha-3-beta-4 IC50
121 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-3-beta-4 IC50
148 nM
 . . [1], [2], [3], [4]
 Target Info    nAChR alpha-7 IC50
3 μM
 . . [1], [2], [3], [4]
References
Ref 1 A novel 4/7-conotoxin LvIA from Conus lividus that selectively blocks 32 vs. 6/323 nicotinic acetylcholine receptors. FASEB J. 2014 Apr;28(4):1842-53. doi: 10.1096/fj.13-244103. Epub 2014 Jan 7.
Ref 2 Recombinant Expression and Characterization of -Conotoxin LvIA in Escherichia coli. Mar Drugs. 2016 Jan 5;14(1):11. doi: 10.3390/md14010011.
Ref 3 -Conotoxins Identify the 34* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells. Mol Pharmacol. 2015 Nov;88(5):881-93. doi: 10.1124/mol.115.100982. Epub 2015 Sep 1.
Ref 4 Correction to "-Conotoxins Identify the 34* Subtype as the Predominant Nicotinic Acetylcholine Receptor Expressed in Human Adrenal Chromaffin Cells". Mol Pharmacol. 2016 Feb;89(2):322. doi: 10.1124/mol.115.100982err.
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