Peptide Information

General Information of This Peptide
Peptide ID
BTDP003646
Peptide Name
Kunitz-type serine protease inhibitor DrKIn-II
Symonym
Daboia russelii Kunitz Inhibitor-II
Species
Daboia russelii (Russel's viper) (Vipera russelii)
Uniprot Name
VKTK2_DABRR
Alphafold ID
H6VC06
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: H6VC06
Sequence
MSSGGLLLLLGLLTLWAELTPISGHDRPTFCNLAPESGRCRAHLRRIYYNLESNKCEVFF
YGGCGGNDNNFSTWDECRHTCVGK
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Sequence Length
84
Mass (Da)
9385
Signal Sequence
MSSGGLLLLLGLLTLWAELTPISG
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Sequence Removed Signal Peptide
HDRPTFCNLAPESGRCRAHLRRIYYNLESNKCEVFFYGGCGGNDNNFSTWDECRHTCVGK
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Disulfide Bond
31-81;40-64;56-77
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Daboia
Species: Daboia russelii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    plasmin Inhibition constant
0.19 nM
 . . [1], [2]
 Target Info    coagulation FXIa (F11) Inhibition constant
6 nM
 . . [1], [2]
References
Ref 1 A novel heparin-dependent inhibitor of activated protein C that potentiates consumptive coagulopathy in Russell's viper envenomation. J Biol Chem. 2012 May 4;287(19):15739-48. doi: 10.1074/jbc.M111.323063. Epub 2012 Mar 13.
Ref 2 Functional characterization of a slow and tight-binding inhibitor of plasmin isolated from Russell's viper venom. Biochim Biophys Acta. 2014 Jan;1840(1):153-9. doi: 10.1016/j.bbagen.2013.08.019. Epub 2013 Aug 30.
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