Peptide Information

General Information of This Peptide
Peptide ID
BTDP003645
Peptide Name
Kunitz-type serine protease inhibitor DrKIn-I
Symonym
Daboia russelii Kunitz Inhibitor-I
Species
Daboia russelii (Russel's viper) (Vipera russelii)
Uniprot Name
VKTK1_DABRR
Alphafold ID
H6VC05
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: H6VC05
Sequence
MSSGGLLLLLGLLTLWAELTPISGQDRPKFCNLAPESGRCRGHLRRIYYNPDSNKCEVFF
YGGCGGNDNNFETRKKCRQTCGAPRKGRPT
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Sequence Length
90
Mass (Da)
10010
Signal Sequence
MSSGGLLLLLGLLTLWAELTPISG
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Sequence Removed Signal Peptide
QDRPKFCNLAPESGRCRGHLRRIYYNPDSNKCEVFFYGGCGGNDNNFETRKKCRQTCGAP
RKGRPT
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Disulfide Bond
31-81;40-64;56-77
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Daboia
Species: Daboia russelii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    coagulation FXIa (F11) Inhibition rate
40 %
 . . [1]
 Target Info    trypsin Inhibition rate
45 %
 . . [1]
 Target Info    plasmin Inhibition rate
70 %
 . . [1]
 Target Info    activated protein C (APC) IC50
3.5 nM
 . . [1]
 Target Info    activated protein C (APC) IC50
88.9 nM
 . . [1]
References
Ref 1 A novel heparin-dependent inhibitor of activated protein C that potentiates consumptive coagulopathy in Russell's viper envenomation. J Biol Chem. 2012 May 4;287(19):15739-48. doi: 10.1074/jbc.M111.323063. Epub 2012 Mar 13.
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