Peptide Information

General Information of This Peptide
Peptide ID
BTDP002626
Peptide Name
Pi-theraphotoxin-Hm3a
Symonym
Pi-TRTX-Hm3a
Species
Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)
Uniprot Name
TX3A_HETMC
Alphafold ID
C0HKD0
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: C0HKD0
Sequence
EPCIPKWKSCVNRHGDCCAGLECWKRRKSFEVCVPKV
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Sequence Length
37
Mass (Da)
4293
Sequence Removed Signal Peptide
EPCIPKWKSCVNRHGDCCAGLECWKRRKSFEVCVPKV
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Disulfide Bond
3-18;10-23;17-33
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Heteroscodra
Species: Heteroscodra maculata
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    acid-sensing ion channel (ASIC) Effective concentration 50
17.4 nM
 . . [1]
 Target Info    acid-sensing ion channel (ASIC) Effective concentration 50
46.5 nM
 . . [1]
 Target Info    ASIC1b Effective concentration 50
178.1 nM
 . . [1]
 Target Info    acid-sensing ion channel (ASIC) IC50
1.3 nM
 .
Provoke a pH-dependent inhibition
 [1]
 Target Info    ASIC1b IC50
39.7 nM
 .
Provoke a pH-dependent inhibition
 [1]
References
Ref 1 Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1. Neuropharmacology. 2017 Dec;127:185-195. doi: 10.1016/j.neuropharm.2017.03.020. Epub 2017 Mar 19.
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