Peptide Information

General Information of This Peptide
Peptide ID
BTDP002228
Peptide Name
U1-theraphotoxin-Ap1a
Symonym
U1-TRTX-Ap1a
Species
Acanthoscurria paulensis (Brazilian giant black tarantula spider)
Uniprot Name
TXA1_ACAPA
Alphafold ID
B3EWY4
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: B3EWY4
Sequence
MRSLTLAAVLACSLLLVFHTSAAEELEVQDGHLMNPGDGDTALATVDDERIIECFFSCEI
EKDGKSKEGKPCKPKGDKNKDKKCSGGWRCKIKMCLKI
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Sequence Length
98
Mass (Da)
10747
Signal Sequence
MRSLTLAAVLACSLLLVFHTSAA
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Sequence Removed Signal Peptide
EELEVQDGHLMNPGDGDTALATVDDERIIECFFSCEIEKDGKSKEGKPCKPKGDKNKDKK
CSGGWRCKIKMCLKI
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Disulfide Bond
54-84;58-90;72-95
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Acanthoscurria
Species: Acanthoscurria paulensis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.4 Inhibition rate .
1 μM
 . [1]
 Target Info    Nav1.5 Inhibition rate .
1 μM
 . [1]
 Target Info    Nav1.2 Inhibition rate .
1 μM
 . [1]
 Target Info    Nav1.6 Inhibition rate .
1 μM
 . [1]
References
Ref 1 Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment to the HWTX-II family. Biochemistry. 2013 Apr 9;52(14):2440-52. doi: 10.1021/bi4000035. Epub 2013 Mar 29.
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