Peptide Information

General Information of This Peptide
Peptide ID
BTDP001753
Peptide Name
PI-stichotoxin-Hcr2j
Symonym
Kunitz-peptide HCIQ4c7
Species
Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Uniprot Name
VKT2J_HETCR
Alphafold ID
A0A6B7FA07
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: A0A6B7FA07
Sequence
GFYFRSIQGFYFKRIQGNICSEPKKVGRCRESFPRFYFDSETGKCTPFIYGGCGGNGNNF
ETLHACRAICRA
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Sequence Length
72
Mass (Da)
8206
Sequence Removed Signal Peptide
GFYFRSIQGFYFKRIQGNICSEPKKVGRCRESFPRFYFDSETGKCTPFIYGGCGGNGNNF
ETLHACRAICRA
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Disulfide Bond
20-70;29-53;45-66
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Stichodactylidae
Genus: Radianthus
Species: Radianthus crispa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    P2RX7 Dissociation constant
45.5 μM
 . . [1], [2]
 Target Info    trypsin Inhibition constant
190 nM
 . . [1], [2]
References
Ref 1 A new multigene HCIQ subfamily from the sea anemone Heteractis crispa encodes Kunitz-peptides exhibiting neuroprotective activity against 6-hydroxydopamine. Sci Rep. 2020 Mar 6;10(1):4205. doi: 10.1038/s41598-020-61034-x.
Ref 2 Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson's Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation. Int J Mol Sci. 2022 May 4;23(9):5115. doi: 10.3390/ijms23095115.
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