Peptide Information

General Information of This Peptide
Peptide ID
BTDP001712
Peptide Name
PI-stichotoxin-Hmg3d
Symonym
IQ-peptide; Kunitz-type serine protease inhibitor HMIQ3c1
Species
Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)
Uniprot Name
3DPD_HETMG
Alphafold ID
A0A3G2FQK2
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: A0A3G2FQK2
Sequence
GFYFRSIQGFYFKRIQGNICSEPKKVGRCRGSFPRFYFDSETGKCTPFIYGGCGGNGNNF
ETLRRCRAICRA
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Sequence Length
72
Mass (Da)
8238
Sequence Removed Signal Peptide
GFYFRSIQGFYFKRIQGNICSEPKKVGRCRGSFPRFYFDSETGKCTPFIYGGCGGNGNNF
ETLRRCRAICRA
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Disulfide Bond
20-70;29-53;45-66
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Kingdom: Metazoa
Phylum: Cnidaria
Class: Anthozoa
Order: Actiniaria
Family: Stichodactylidae
Genus: Heteractis
Species: Heteractis magnifica
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    P2RX7 Dissociation constant
43.3 μM
 . . [1]
 Target Info    trypsin Inhibition constant
50 nM
 . . [1]
References
Ref 1 Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson's Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation. Int J Mol Sci. 2022 May 4;23(9):5115. doi: 10.3390/ijms23095115.
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