Peptide Information

General Information of This Peptide
Peptide ID
BTDP001629
Peptide Name
Hi1a
Symonym
Double-knot toxin; SF1 peptide;Pi-hexatoxin-Hi1a
Species
Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Uniprot Name
TP1A_HADIN
Alphafold ID
A0A1L1QJU3
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2N8F
Sequence
NECIRKWLSCVDRKNDCCEGLECYKRRHSFEVCVPIPGFCLVKWKQCDGRERDCCAGLEC
WKRSGNKSSVCAPIT
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Sequence Length
75
Mass (Da)
8648
Sequence Removed Signal Peptide
NECIRKWLSCVDRKNDCCEGLECYKRRHSFEVCVPIPGFCLVKWKQCDGRERDCCAGLEC
WKRSGNKSSVCAPIT
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Disulfide Bond
3-18;10-23;17-33;40-55;47-60;54-71
PDB ID
2N8F
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Hexathelidae
Genus: Hadronyche
Species: Hadronyche infensa
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    acid-sensing ion channel (ASIC) Tau(off)
14.2 min
 .
Inhibit ASIC1a activation in a pH-independent and slowly reversible manner
 [1], [2]
 Target Info    ASIC1b Tau(off)
31.8 min
 .
Inhibit ASIC1a activation in a pH-independent and slowly reversible manner
 [1], [2]
 Target Info    acid-sensing ion channel (ASIC) IC50
0.4 nM
 .
Inhibit ASIC1a activation in a pH-independent and slowly reversible manner
 [1], [2]
 Target Info    ASIC1b IC50
0.52 nM
 .
Inhibit ASIC1a activation in a pH-independent and slowly reversible manner
 [1], [2]
References
Ref 1 Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3750-3755. doi: 10.1073/pnas.1614728114. Epub 2017 Mar 20.
Ref 2 The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. Vet Parasitol. 2019 Jun;270:40-46. doi: 10.1016/j.vetpar.2019.05.008. Epub 2019 May 19.
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