Peptide Information

General Information of This Peptide
Peptide ID
BTDP001583
Peptide Name
Metalloendopeptidase
Symonym
EC 3.4.24.-
Species
Brugia malayi (Filarial nematode worm)
Uniprot Name
A0A0J9XQE3_BRUMA
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MCR
Sequence
CEDLNAHCEMWQQLGHCQYSPKYMGHYCKKACGLC
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Sequence Length
35
Mass (Da)
4074
Sequence Removed Signal Peptide
CEDLNAHCEMWQQLGHCQYSPKYMGHYCKKACGLC
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Disulfide Bond
383-417;390-410;399-414;435-469
PDB ID
2MCR
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Kingdom: Metazoa
Phylum: Nematoda
Class: Chromadorea
Order: Rhabditida
Family: Onchocercidae
Genus: Brugia
Species: Brugia malayi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 IC50
6.9 μM
 . . [1], [2]
References
Ref 1 Draft genome of the filarial nematode parasite Brugia malayi. Science. 2007 Sep 21;317(5845):1756-60. doi: 10.1126/science.1145406.
Ref 2 Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB J. 2014 Sep;28(9):3952-64. doi: 10.1096/fj.14-251967. Epub 2014 Jun 2.
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