Peptide Information

General Information of This Peptide
Peptide ID
BTDP001534
Peptide Name
Conotoxin Bt1.8
Species
Conus betulinus (Beech cone)
Uniprot Name
CA18_CONBE
Alphafold ID
A0A068B6Q6
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2NAY
Sequence
PDGRNAAAKAFDLITPTVRKGCCSNPACILNNPNQCG
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Sequence Length
37
Mass (Da)
3831
Sequence Removed Signal Peptide
PDGRNAAAKAFDLITPTVRKGCCSNPACILNNPNQCG
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Disulfide Bond
22-28;23-36
PDB ID
2NAY
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus betulinus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-6/alpha-3-beta-4 IC50
>100 nM
 . . [1]
 Target Info    nAChR alpha-6/alpha-3-beta-2-beta-3 IC50
1.7 nM
 . . [1]
 Target Info    nAChR alpha-6/alpha-3-beta-2-beta-3 IC50
2.1 nM
 . . [1]
 Target Info    nAChR alpha-3-beta-2 IC50
8.8 nM
 . . [1]
 Target Info    nAChR alpha-3-beta-2 IC50
9.4 nM
 . . [1]
 Target Info    nAChR alpha-7 IC50
>10 μM
 . . [1]
 Target Info    nAChR alpha-2-beta-2 IC50
>10 μM
 . . [1]
 Target Info    nAChR alpha-2-beta-4 IC50
>10 μM
 . . [1]
 Target Info    nAChR alpha-4-beta-2 IC50
>10 μM
 . . [1]
 Target Info    nAChR alpha-4-beta-4 IC50
>10 μM
 . . [1]
 Target Info    nAChR alpha-9-alpha-10 IC50
>10 μM
 . . [1]
 Target Info    nAChR alpha-6/alpha3-alpha-4-beta-2 IC50
>3 μM
 . . [1]
 Target Info    nAChR alpha-3-beta-4 IC50
2.15 μM
 . . [1]
References
Ref 1 -Conotoxin Bt1.8 from Conus betulinus selectively inhibits 6/323 and 32 nicotinic acetylcholine receptor subtypes. J Neurochem. 2021 Oct;159(1):90-100. doi: 10.1111/jnc.15434. Epub 2021 Jun 22.
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