Peptide Information

General Information of This Peptide
Peptide ID
BTDP001509
Peptide Name
ShKT domain-containing protein
Species
Ancylostoma ceylanicum
Uniprot Name
A0A016UNP9_9BILA
Alphafold ID
A0A016UNP9
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MD0
Sequence
CADEKGYDCSRHKVNGDCDNDDKLLEMGYYCPVTCGFCEP
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Sequence Length
40
Mass (Da)
4489
Sequence Removed Signal Peptide
CADEKGYDCSRHKVNGDCDNDDKLLEMGYYCPVTCGFCEP
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Disulfide Bond
28-65;36-58;45-62
PDB ID
2MD0
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Kingdom: Metazoa
Phylum: Nematoda
Class: Chromadorea
Order: Rhabditida
Family: Ancylostomatidae
Genus: Ancylostoma
Species: Ancylostoma ceylanicum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
1.5 μM
 . [1], [2]
 Target Info    Kv1.3 IC50
266 nM
 . . [1], [2]
References
Ref 1 Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB J. 2014 Sep;28(9):3952-64. doi: 10.1096/fj.14-251967. Epub 2014 Jun 2.
Ref 2 The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families. Nat Genet. 2015 Apr;47(4):416-22. doi: 10.1038/ng.3237. Epub 2015 Mar 2.
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