Peptide Information

General Information of This Peptide
Peptide ID
BTDP001139
Peptide Name
PTx2-11
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
YCQKWMWTCDSERKCCEGMVCRLWCKKKLW
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Mutant Sequence
[Ac]CQEFLKPCDSERKCCEGLECKLWCKKKLW
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Sequence Length
30
Sequence Removed Signal Peptide
[Ac]CQEFLKPCDSERKCCEGLECKLWCKKKLW
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Disulfide Bond
2-16;9-21;15-25
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
113 ± 10 nM
 . . [1]
 Target Info    Nav1.4 IC50
>17 μM
 . . [1]
 Target Info    Nav1.6 IC50
>17 μM
 . . [1]
References
Ref 1 Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na(v)1.7 for the Treatment of Pain. J Med Chem. 2022 Jan 13;65(1):485-496. doi: 10.1021/acs.jmedchem.1c01570. Epub 2021 Dec 21.
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