Peptide Information

General Information of This Peptide
Peptide ID
BTDP001076
Peptide Name
MTX (N21Y,A22G,I25M,K27R,S28K,Y32N,G33R)
Symonym
MTX (N21Y,A22G,I25M,K27R,S28K,Y32N,G33R)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
VSCTGSKDCYAPCRKQTGCPNAKCINKSCKCYGC
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Mutant Sequence
VSCTGSKDCYAPCRKQTGCPYGKCMNRKCKCNRC
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Sequence Length
34
Mass(Da)
3784
Sequence Removed Signal Peptide
VSCTGSKDCYAPCRKQTGCPYGKCMNRKCKCNRC
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 IC50
1 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
4 nM
 .
Blocker
 [1]
 Target Info    KCa3.1 IC50
460 nM
 .
Blocker
 [1]
References
Ref 1 Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins. J Biol Chem. 2004 Dec 31;279(53):55690-6. doi: 10.1074/jbc.M410055200. Epub 2004 Oct 21.
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