Peptide Information

General Information of This Peptide
Peptide ID
BTDP001028
Peptide Name
Pi1 (K24A,Y33A)
Symonym
Pi1 (K24A,Y33A)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
LVKCRGTSDCGAPCQQQTGCPNSKCINRMCKCYGC
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Mutant Sequence
LVKCRGTSDCGRPCQQQTGCPNSACINRMCKCAGC
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Sequence Length
35
Mass(Da)
3684
Sequence Removed Signal Peptide
LVKCRGTSDCGRPCQQQTGCPNSACINRMCKCAGC
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2 IC50
30 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
22 μM
 .
Blocker
 [1]
References
Ref 1 The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels. Biochem J. 2004 Jan 1;377(Pt 1):25-36. doi: 10.1042/BJ20030115.
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