Peptide Information

General Information of This Peptide
Peptide ID
BTDP000973
Peptide Name
OsK1 (E16K,K20D,T36Y)
Symonym
OsK1 (E16K,K20D,T36Y)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
GVIINVKCKISRQCLEPCKKAGMRFGKCMNGKCHCTPK
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Mutant Sequence
GVIINVKCKISRQCLKPCKDAGMRFGKCMNGKCHCYPK
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Sequence Length
38
Mass(Da)
4253
Sequence Removed Signal Peptide
GVIINVKCKISRQCLKPCKDAGMRFGKCMNGKCHCYPK
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv3.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.6 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa1.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.7 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.1 IC50
34.4 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
232 nM
 .
Blocker
 [1]
References
Ref 1 K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. Biochem J. 2005 Jan 1;385(Pt 1):95-104. doi: 10.1042/BJ20041379.
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