Peptide Information

General Information of This Peptide
Peptide ID
BTDP000916
Peptide Name
Toxin MeKTx13-3 (D33H)
Symonym
Toxin MeKTx13-3 (D33H)
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
?
Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
VGINVKCKHSGQCLKPCKDAGMRFGKCINGKCDCTPK
   Click to Show/Hide
Mutant Sequence
VGINVKCKHSGQCLKPCKDAGMRFGKCINGKCHCTPK
   Click to Show/Hide
Sequence Length
37
Mass(Da)
3985
Sequence Removed Signal Peptide
VGINVKCKHSGQCLKPCKDAGMRFGKCINGKCHCTPK
   Click to Show/Hide
        Click to Show/Hide the Complete Species Lineage
N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa3.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.7 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv11.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2.2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2.3 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate
46 %
1 μM
Blocker
 [1]
 Target Info    Kv1.3 IC50
0.015 nM
 .
Blocker
 [2]
References
Ref 1 The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases. Toxins (Basel). 2016 Apr 19;8(4):115. doi: 10.3390/toxins8040115.
Ref 2 Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues. Biochem Biophys Res Commun. 2014 Apr 25;447(1):70-6. doi: 10.1016/j.bbrc.2014.03.101. Epub 2014 Apr 3.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.