Peptide Information

General Information of This Peptide
Peptide ID
BTDP000862
Peptide Name
IbTx (D4N,D6N,S10A,D19N,D24N)
Symonym
IbTx (D4N,D6N,S10A,D19N,D24N)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
QFTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS
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Mutant Sequence
QFTNVNCSVAKECWSVCKNLFGVNRGKCMGKKCRCYQ
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Sequence Length
37
Mass(Da)
4211
Sequence Removed Signal Peptide
QFTNVNCSVAKECWSVCKNLFGVNRGKCMGKKCRCYQ
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa1.1 Inhibition constant
0.027 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 Inhibition rate .
300 nM
Blocker
 [1]
References
Ref 1 Glycine 30 in iberiotoxin is a critical determinant of its specificity for maxi-K versus K(V) channels. FEBS Lett. 2002 Sep 11;527(1-3):298-302. doi: 10.1016/s0014-5793(02)03256-8.
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