Peptide Information

General Information of This Peptide
Peptide ID
BTDP000715
Peptide Name
P[G5]K
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
DCLGFLWKCNPSNDKCCRPNLVCSRKDKWCKYQILPATGG
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Mutant Sequence
DCLGFLWKCNPSNDKCCRPNLVCSRKDKWCKYQILPATGGGGGCCNCSSKWCRDHSRCC
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Sequence Length
59
Mass(Da)
6607
Sequence Removed Signal Peptide
DCLGFLWKCNPSNDKCCRPNLVCSRKDKWCKYQILPATGGGGGCCNCSSKWCRDHSRCC
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Disulfide Bond
2-17;9-23;16-30;44-52;45-58;47-59
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
58 nM
 . . [1]
References
Ref 1 Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel Na(V)1.7 Inhibition. Bioconjug Chem. 2020 Jan 15;31(1):64-73. doi: 10.1021/acs.bioconjchem.9b00744. Epub 2019 Dec 16.
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