Peptide Information

General Information of This Peptide
Peptide ID
BTDP000584
Peptide Name
KIIIA
Species
Conus rolani (Cone snail)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
CCNCSSKWCRDHSRCC
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Sequence Length
16
Mass (Da)
1891
Sequence Removed Signal Peptide
CCNCSSKWCRDHSRCC
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Disulfide Bond
1-9;2-15;4-16
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus rolani
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
363 nM
 . . [1]
References
Ref 1 Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel Na(V)1.7 Inhibition. Bioconjug Chem. 2020 Jan 15;31(1):64-73. doi: 10.1021/acs.bioconjchem.9b00744. Epub 2019 Dec 16.
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