Peptide Information

General Information of This Peptide
Peptide ID
BTDP000578
Peptide Name
Potassium channel toxin ShK (K22N,Q24R)
Symonym
Potassium channel toxin ShK (K22N,Q24R)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
RSCIDTIPKSRCTAFKCKHSMKYRLSFCRKTCGTC
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Mutant Sequence
RSCIDTIPKSRCTAFQCKHSMNYRLSFCRKTCGTC
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Sequence Length
35
Mass(Da)
4041
Sequence Removed Signal Peptide
RSCIDTIPKSRCTAFQCKHSMNYRLSFCRKTCGTC
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Inhibition constant
1.2 nM
 .
Blocker
 [1]
References
Ref 1 Tethered peptide neurotoxins display two blocking mechanisms in the K(+) channel pore as do their untethered analogs. Sci Adv. 2020 Mar 4;6(10):eaaz3439. doi: 10.1126/sciadv.aaz3439. eCollection 2020 Mar.
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