Peptide Information

General Information of This Peptide
Peptide ID
BTDP000253
Peptide Name
HNTX-III
Species
Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
GCKGFGDSCTPGKNECCPNYACSSKHKWCKVYL
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Sequence Length
33
Mass (Da)
3615
Sequence Removed Signal Peptide
GCKGFGDSCTPGKNECCPNYACSSKHKWCKVYL
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Disulfide Bond
2-17;9-22;17-29
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Haplopelma
Species: Haplopelma hainanum
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
0.211 ± 0.049 μM
 . . [1]
References
Ref 1 Engineering of highly potent and selective HNTX-III mutant against hNa(v)1.7 sodium channel for treatment of pain. J Biol Chem. 2021 Jan-Jun;296:100326. doi: 10.1016/j.jbc.2021.100326. Epub 2021 Jan 23.
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