Peptide Information

General Information of This Peptide
Peptide ID
BTDP000252
Peptide Name
HNTXI (E1G,R25K,D26H,L32W)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
ECKGFGKSCVPGKNECCSGYACNSRDKWCKVLL
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Mutant Sequence
GCKGFGKSCVPGKNECCSGYACNSKHKWCKVWL
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Sequence Length
33
Mass(Da)
3609
Sequence Removed Signal Peptide
GCKGFGKSCVPGKNECCSGYACNSKHKWCKVWL
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Disulfide Bond
2-17;9-22;16-29
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
0.669 ± 0.070 μM
 . . [1]
References
Ref 1 Engineering Gain-of-Function Analogues of the Spider Venom Peptide HNTX-I, A Potent Blocker of the hNa(V)1.7 Sodium Channel. Toxins (Basel). 2018 Sep 4;10(9):358. doi: 10.3390/toxins10090358.
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