General Information of This Peptide
Peptide ID
BTDP000094
Peptide Name
E1A,E4A,Y33W
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
ECLEIFKACNPSNDQCCKSSKLVCSRKTRWCKYQI
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Mutant Sequence
ACLAIFKACNPSNDQCCKSSKLVCSRKTRWCKWQI
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Sequence Length
35
Mass(Da)
4021
Sequence Removed Signal Peptide
ACLAIFKACNPSNDQCCKSSKLVCSRKTRWCKWQI
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Disulfide Bond
2-17;9-24;16-31
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
0.6 ± 0.1 nM
. . [1]
References
Ref 1 Potency optimization of Huwentoxin-IV on hNav1.7: a neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena. Peptides. 2013 Jun;44:40-6. doi: 10.1016/j.peptides.2013.03.011. Epub 2013 Mar 19.
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