Peptide Information

General Information of This Peptide
Peptide ID
BTDP000025
Peptide Name
AM-8145-11
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
YCQKWMWTCDSKRACCEGLRCKLWCRKII
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Mutant Sequence
[Pra]YCQK[2-Nal5][Nle]WTCDSKRACCEGLRCKLWCRKEI
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Sequence Length
30
Mass(Da)
3709
Sequence Removed Signal Peptide
[Pra]YCQK[2-Nal5][Nle]WTCDSKRACCEGLRCKLWCRKEI
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Disulfide Bond
3-17;10-22;16-26
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
22 nM
 . . [1]
References
Ref 1 Discovery of Tarantula Venom-Derived Na(V)1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis. J Med Chem. 2018 Nov 8;61(21):9500-9512. doi: 10.1021/acs.jmedchem.8b00736. Epub 2018 Oct 22.
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