Peptide Information

General Information of This Peptide
Peptide ID
BTDP000022
Peptide Name
AM-8145
3D Structure
Original Sequence
YCQKWMWTCDSKRACCEGLRCKLWCRKII
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Mutant Sequence
[Pra]YCQKW[Nle]WTCDSKRACCEGLRCKLWCRKEI
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Sequence Length
30
Mass(Da)
3698
Sequence Removed Signal Peptide
[Pra]YCQKW[Nle]WTCDSKRACCEGLRCKLWCRKEI
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Disulfide Bond
3-17;10-22;16-26
PDB ID
6CGW
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
0.5 nM
 . . [1]
References
Ref 1 Discovery of Tarantula Venom-Derived Na(V)1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis. J Med Chem. 2018 Nov 8;61(21):9500-9512. doi: 10.1021/acs.jmedchem.8b00736. Epub 2018 Oct 22.
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