Target Information

General Information of This Target
Target ID
BTDT00226
Target Name
G protein-activated inward rectifier potassium channel 1 (Kcnj3);G protein-activated inward rectifier potassium channel 4 (Kcnj5)
Target Bioclass
Transporter and channel
Uniprot ID
P63250 ; P48545
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
Kcnj3;Kcnj5
Gene ID
16519 ; 16521
Synonym 1
Inward rectifier K(+) channel Kir3.1; Potassium channel, inwardly rectifying subfamily J member 3
Synonym 2
Cardiac inward rectifier; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; KATP-1; Potassium channel, inwardly rectifying subfamily J member 5
Sequence 1
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQGPQQQLVPKKKRQRFVDKNGRCNVQHGNL
GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY
TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM
FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE
GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEVVVILE
GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE
QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDISTKLPSKLQKITGREDFPKKLLRMS
STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG
PTRMEGNLPAKLRKMNSDRFT

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Sequence 2
MAGDSRNAMNQDMEIGVTSQDHKKIPKQARDYIPIATDRTRLLTEGKKPRQRYMEKTGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTITWLFFGFIWWLIAYVRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINEKSPFWEMSRAQLEQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKRSGRLLQYLPSPPLLGGCAEAGNEAEAEKDEEGEPNGLSVSQATRGSM

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Family1
the inward rectifier-type potassium channel (TC 1.A.2.1) family.
Family2
the inward rectifier-type potassium channel (TC 1.A.2.1) family
Function 1
This potassium channel is controlled by G proteins. Inward; rectifier potassium channels are characterized by a greater tendency to; allow potassium to flow into the cell rather than out of it. Their; voltage dependence is regulated by the concentration of extracellular; potassium; as external potassium is raised, the voltage range of the; channel opening shifts to more positive voltages. The inward; rectification is mainly due to the blockage of outward current by; internal magnesium. This receptor plays a crucial role in regulating; the heartbeat.

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Function 2
This potassium channel is controlled by G proteins. Inward; rectifier potassium channels are characterized by a greater tendency to; allow potassium to flow into the cell rather than out of it. Their; voltage dependence is regulated by the concentration of extracellular; potassium; as external potassium is raised, the voltage range of the; channel opening shifts to more positive voltages. The inward; rectification is mainly due to the blockage of outward current by; internal magnesium. Can be blocked by external barium.

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Taxonomy ID
10090
TCDB ID
. ; .
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
References
Ref 1 Antidepressive effect of an inward rectifier K+ channel blocker peptide, tertiapin-RQ. PLoS One. 2020 Nov 13;15(11):e0233815. doi: 10.1371/journal.pone.0233815. eCollection 2020.
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