Target Information

General Information of This Target
Target ID
BTDT00198
Target Name
Voltage-gated potassium channel subunit beta-1 (KCNAB1)
Target Bioclass
Enzyme
Uniprot ID
Q9PWR1
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
?
Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
KCNAB1
Gene ID
395730
Synonym
KVB1.1; K(+) channel subunit beta-1; Kv-beta-1
Sequence
MQVSIACTEHNLKSRNGEERLISKQNAAAPNVVNAARAKFRTVAIIARSLGTFTPQHHIS
LKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAEQLMTIAYESGVNLFDT
AEVYAAGKAEVILGNILKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLRASLQR
LQLEYVDVVFANRPDNNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFN
LIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRAA
LKCYQWLKEKIISEEGRKQQTKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSN
PEQLIENLGAIQVLPKMTSHIVNEIDNILGNKPYSKKDYRS

    Click to Show/Hide
Family
the shaker potassium channel beta subunit family
Function
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Binds NADPH; this is required for efficient down- regulation of potassium channel activity. Has NADPH- dependent aldoketoreductase activity. Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity.

    Click to Show/Hide
Taxonomy ID
9031
EC Number
1.1.1.-
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Aves
Order: Galliformes
Family: Phasianidae
Genus: Gallus
Species: Gallus gallus
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Beta-1-bungarotoxin Dissociation constant
0.47 nM
 [1]
References
Ref 1 Binding of beta-bungarotoxin to synaptic membrane fractions of chick brain. J Biol Chem. 1982 Sep 10;257(17):10015-22.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.