Target Information

General Information of This Target
Target ID
BTDT00132
Target Name
Potassium channel toxin alpha-KTx 6.1
Target Bioclass
Transporter and channel
Uniprot ID
Q10726
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Synonym
PiTX-K-gamma; Potassium channel-blocking toxin 1
Sequence
LVKCRGTSDCGRPCQQQTGCPNSKCINRMCKCYGC

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Family
the short scorpion toxin superfamily.Potassium channel inhibitor family
Function
Potently and reversibly inhibits the insect voltage-gated Shaker (Sh) potassium channel (isoform alpha (B)), the mammalian voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=0.44 nM), and the calcium-activated potassium channel KCa2.3/KCNN3 (Kd=330 nM). Its effect on Kv1.3/KCNA3 is controversial, since this channel is voltage- independently inhibited in but is not affected in . Furthermore, this toxin competes with apamin (a small conductance calcium-activated potassium channel inhibitor) for binding to rat brain synaptosomes.

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Taxonomy ID
55084
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Pandinus
Species: Pandinus imperator
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Toxin II.10.4 (7TP,D9Q) Dissociation constant
88 nM
 [1]
References
Ref 1 Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels. Biochem J. 2004 Jan 1;377(Pt 1):37-49. doi: 10.1042/BJ20030977.
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