Target Information

General Information of This Target
Target ID
BTDT00033
Target Name
Acetylcholine receptor subunit gamma (CHRNG)
Target Bioclass
Transporter and channel
Uniprot ID
P02714
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
?
Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
CHRNG
Sequence
MVLTLLLIICLALEVRSENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISL
NEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVA
YYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAE
EGEAVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYI
INIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLI
GKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLEPSEET
PEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLY
KDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGT
LAIFLTGHFNQVPEFPFPGDPRKYVP

    Click to Show/Hide
Family
the ligand-gated ion channel (TC 1.A.9) family
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

    Click to Show/Hide
Taxonomy ID
7787
TCDB ID
1.A.9.1.9
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Chondrichthyes
Order: Torpediniformes
Family: Torpedinidae
Genus: Tetronarce
Species: Tetronarce californica
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Short neurotoxin 6 IC50
0.18 μM
 [1], [2], [3]
 Toxin Info    Short neurotoxin 7 IC50
0.3 μM
 [1], [2], [3]
 Toxin Info    Short neurotoxin 3 IC50
0.3 μM
 [1], [2], [3]
 Toxin Info    Short neurotoxin 2 IC50
0.3 μM
 [1], [2], [3]
References
Ref 1 Postsynaptic short-chain neurotoxins from Pseudonaja textilis. cDNA cloning, expression and protein characterization. Eur J Biochem. 1999 Nov;265(3):982-9. doi: 10.1046/j.1432-1327.1999.00800.x.
Ref 2 Molecular cloning, characterization and evolution of the gene encoding a new group of short-chain alpha-neurotoxins in an Australian elapid, Pseudonaja textilis. FEBS Lett. 2000 May 19;473(3):303-10. doi: 10.1016/s0014-5793(00)01549-0.
Ref 3 Molecular diversity in venom from the Australian Brown snake, Pseudonaja textilis. Mol Cell Proteomics. 2006 Feb;5(2):379-89. doi: 10.1074/mcp.M500270-MCP200. Epub 2005 Nov 10.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.