Target Information

General Information of This Target
Target ID
BTDT00001
Target Name
Adipokinetic hormone/corazonin-related peptide receptor variant I
Target Bioclass
Receptor
Uniprot ID
A0A2L0VBG2
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Synonym
ACPr1; GnRH-related neuropeptide receptor
Sequence
MYLSAGLRKIMDNPPVTSKYQHRSQDEMLSANLNHQQTTNGSPSTTMMLGGDAAAVAFAS
SSSNGAGDAYFRGLAALTGNASGISSMDMSNSTETGIVAPGHTETTVAVIIVYCVLFIIA
AGGNLSVVITLFRSRRHRRSRVSLMICHLAVADLMVAFIMIPLEVGWRITVQWHAGNVAC
KVFLFMRAFCLYLSSNVLVCVSLDRCFAVIYPLRVSAARKRGKIMLGGAWFIAFANAIPQ
SIIFRVQHHPNVPDFTQCVTFGFFTTPAMETAYNLFCVVAMYFMPLMVISAAYTVILCEI
SNRSREKETSDTSHTGGMRLRCNDLTHIERARQRTLRLTITIVVVFVWCWTPYVVMTLWY
MFDRESALKVDGAIQDGLFLMAVSNSCMNPLVYGSYAMKCRRPWRRQMAPNGVQTPNAAQ
RRSTDAVSGMVGPHSDRLTGRDNKDELVYEGGGTERNKLKQFGMANGIFARIGSTGRNHV
TMAGGGAAGTSVATTRFGNCTTTVGGRNVTEPIRTVAMSSGSRVKSFQPSYSEFVMMADE
RSLMLSRPSFYSDPTPNEFDSTVDCGLTRSLDTGGWR

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Family
the G-protein coupled receptor 1 family
Function
G-protein coupled receptor specific for adipokinetic hormone/corazonin-related peptide (ACP) (EC(50)=10.25 nM). Is not activated by the closely related peptides AKH and CRZ, or other tested peptides.

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Taxonomy ID
7159
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Diptera
Family: Culicidae
Genus: Aedes
Species: Aedes aegypti
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Z-limacoditoxin(1)-Dv1 Effective concentration 50
0.55 nM
 [1]
 Toxin Info    Z-limacoditoxin(1)-Dv4 Effective concentration 50
3.07 nM
 [1]
References
Ref 1 Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans. Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2023815118. doi: 10.1073/pnas.2023815118.
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