Peptide Information

General Information of This Peptide
Peptide ID
BTDP008803
Peptide Name
ShK-Lys
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTCK
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Sequence Length
36
Mass (Da)
4182
Sequence Removed Signal Peptide
RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTCK
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Disulfide Bond
3-28;12-32;17-35
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 IC50
0.026 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 IC50
0.942 nM
 .
Blocker
 [1]
References
Ref 1 A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3. FEBS Lett. 2012 Nov 16;586(22):3996-4001. doi: 10.1016/j.febslet.2012.09.038. Epub 2012 Oct 9.
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