Peptide Information

General Information of This Peptide
Peptide ID
BTDP008725
Peptide Name
Potassium channel toxin alpha-KTx 16.2
Symonym
BmK 622; BmTx3B; Martentoxin
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KA162_MESMA
Alphafold ID
Q9NBG9
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1M2S
Sequence
MKIFSILLVALIICSISICTEAFGLIDVKCFASSECWTACKKVTGSGQGKCQNNQCRCY
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Sequence Length
59
Mass (Da)
6429
Signal Sequence
MKIFSILLVALIICSISICTEA
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Sequence Removed Signal Peptide
FGLIDVKCFASSECWTACKKVTGSGQGKCQNNQCRCY
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Disulfide Bond
30-51;36-56;40-58
PDB ID
1M2S
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv3.1 Inhibition rate .
100 μM
Blocker
 [7]
 Target Info    Kv4.1 Inhibition rate .
100 μM
Blocker
 [7]
 Target Info    Kv1.3 Inhibition rate
20 %
1 μM
Blocker
 [7]
 Target Info    KCa1.1 IC50
21 nM
 .
Blocker
 [1- 6]
References
Ref 1 Martentoxin, a novel K+-channel-blocking peptide: purification, cDNA and genomic cloning, and electrophysiological and pharmacological characterization. J Neurochem. 2003 Jan;84(2):325-35. doi: 10.1046/j.1471-4159.2003.01516.x.
Ref 2 Molecular divergence of two orthologous scorpion toxins affecting potassium channels. Comp Biochem Physiol A Mol Integr Physiol. 2011 Jul;159(3):313-21. doi: 10.1016/j.cbpa.2011.03.027. Epub 2011 Apr 3.
Ref 3 Purification, characterization of two peptides from Buthus martensi Karch. J Pept Res. 2003 Dec;62(6):252-9. doi: 10.1046/j.1399-3011.2003.00095.x.
Ref 4 Short-chain peptides identification of scorpion Buthus martensi Karsch venom by employing high orthogonal 2D-HPLC system and tandem mass spectrometry. Proteomics. 2012 Oct;12(19-20):3076-84. doi: 10.1002/pmic.201200224. Epub 2012 Sep 19.
Ref 5 Inhibition of martentoxin on neuronal BK channel subtype (alpha+beta4): implications for a novel interaction model. Biophys J. 2008 May 1;94(9):3706-13. doi: 10.1529/biophysj.107.122150. Epub 2008 Jan 16.
Ref 6 The solution structure of BmTx3B, a member of the scorpion toxin subfamily alpha-KTx 16. Proteins. 2005 Feb 1;58(2):489-97. doi: 10.1002/prot.20322.
Ref 7 Recombinant expression and functional characterization of martentoxin: a selective inhibitor for BK channel ( + 4). Toxins (Basel). 2014 Apr 22;6(4):1419-33. doi: 10.3390/toxins6041419.
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